邓节，男，群众，专业：细胞生物学。专业技能：熟练掌握原代细胞（间充质干细胞、肝细胞、尿液细胞）及多能干细胞（iPSCs/PSCs）和小鼠胚胎干细胞的分离培养与诱导分化，系统掌握质粒构建、慢/逆病毒包装、CRISPR-Cas9（敲除/敲减）及dCas9（内源性激活）基因编辑、shRNA/CRISPR-Screen筛选，以及免疫组化、流式、Western blot、ChIP等蛋白/RNA分析技术，并具备小动物肝脏插管、尾静脉/颅内注射等手术操作能力。
一、教育背景：
2008.9-2012.6 理学学士四川大学生命科学与技术基地班
2012.9-2020.6 理学博士四川大学华西医院生物治疗国家重点实验室/生物治疗合作创新中心
二、工作经历：
2020.8-2022.8 博士后 中国科学院广州生物医药与健康研究院/生物岛实验室
2022.9-2024.9 博士后/顾问 上海交通大学/上海数因信科智能科技有限公司
2024.9-至今 讲师 四川轻化工大学医学院
三、参与研究项目
1. 干细胞组织工程肝脏的构建及体外实验研究
2. 功能性纳米颗粒激活脱细胞肝支架用于血液排毒的研究
3. 人/大鼠脂肪间充质干细胞成肝诱导分化
4. c-Myc促进细胞转分化为类肝细胞的实验研究
5. 利用新型体外分化系统筛选小鼠原条发生关键基因
1. Jie Deng; Kai Luo; Pengchao Xu; Qingyuan Jiang; Yuan Wang; Yunqi Yao; Xiaolei Chen; Fuyi Cheng; Dan Xie; Hongxin Deng ; High-efficiency c-Myc-mediated induction of functional hepatoblasts from the human umbilical cord mesenchymal stem cells, Stem Cell Research & Therapy, 2021, 2021(12) (IF= 7.5; 第一作者 )
2. Fen Xu, Tianyi Kang, Jie Deng, Junli Liu, Xiaolei Chen, Yuan Wang, Liang Ouyang, Ting Du, Hong Tang, Xiaoping Xu, Shaochen Chen, Yanan Du, Yujun Shi, Zhiyong Qian, Yuquan Wei, Hongxin Deng, Maling Gou. Functional Nanoparticles Activate a Decellularized Liver Scaffold for Blood Detoxification. Small, 2016 Apr, 12 (15), 2067-76 (IF= 13.3; 共同一作)
3. Yanli Fu, Jie Deng, Qingyuan Jiang, Yuan Wang, Yujing Zhang, Yunqi Yao, Fuyi Cheng, Xiaolei Chen, Fen Xu, Meijuan Huang, Yang Yang, Shuang Zhang, Dechao Yu, Robert Chunhua Zhao, Yuquan Wei, Hongxin Deng. Rapid Generation of Functional Hepatocyte-Like Cells From Human Adipose-Derived Stem Cells.Stem Cell Res Ther, 2016 Aug 5, 7 (1), 105 (IF= 7.5; 共同一作)
4. Fen Xu, Junli Liu, Jie Deng, Xiaolei Chen, Yuan Wang, Pengchao Xu, Lin Cheng, Yanli Fu, Fuyi Cheng, Yunqi Yao, Yujing Zhang, Meijuan Huang, Dechao Yu, Yuquan Wei, Hongxin Deng. Rapid and High-Efficiency Generation of Mature Functional Hepatocyte-Like Cells From Adipose-Derived Stem Cells by a Three-Step Protocol. Stem Cell Res The, 2015 Oct 5, 6, 193 (IF= 7.5; 共同一作)
5. Yuan Wang, Ying Mao, Junfeng Zhang, Gang Shi, Lin Cheng, Yi Lin, Yiming Li, Xiaomei Zhang, Yujing Zhang, Xiaolei Chen, Jie Deng, Xiaolan Su, Lei Dai, Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei, Hongxin Deng. IL-35 Recombinant Protein Reverses Inflammatory Bowel Disease and Psoriasis Through Regulation of Inflammatory Cytokines and Immune Cells. J Cell Mol Med, 2018 Feb 22 (2), 1014-1025(IF= 5.3)
6. Fuyi Cheng, Yujing Zhang, Yuan Wang, Qingyuan Jiang, Cheng Jian Zhao, Jie Deng, Xiaolei Chen, Yunqi Yao, Zhemin Xia, Lin Cheng, Lei Dai, Gang Shi, Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei, Hongxin Deng. Conversion of Human Adipose-Derived Stem Cells Into Functional and Expandable Endothelial-Like Cells for Cell-Based Therapies. Stem Cell Res Ther, 2018 Dec 17, 9 (1), 350 (IF= 7.5)
7. Qin Wang, Lei Dai, Yuan Wang, Jie Deng, Yi Lin, Qingnan Wang, Chao Fang, Zida Ma, Huiling Wang, Gang Shi, Lin Cheng, Yi Liu, Shuang Chen, Junshu Li, Zhexu Dong, Xiaolan Su, Lie Yang, Shuang Zhang, Ming Jiang, Meijuan Huang, Yang Yang, Dechao Yu, Zongguang Zhou, Yuquan Wei, Hongxin Deng.Targeted Demethylation of the SARI Promotor Impairs Colon Tumour Growth. Cancer Lett, 2019 Apr 28, 448, 132-143(IF= 9.7)
8. Yuan Wang, Junli Liu, Qingyuan Jiang, Jie Deng, Fen Xu, Xiaolei Chen, Fuyi Cheng, Yujing Zhang, Yunqi Yao, Zhemin Xia, Xia Xu, Xiaolan Su, Meijuan Huang, Lei Dai, Yang Yang, Shuang Zhang, Dechao Yu, Robert Chunhua Zhao, Yuquan Wei, Hongxin Deng. Human Adipose-Derived Mesenchymal Stem Cell-Secreted CXCL1 and CXCL8 Facilitate Breast Tumor Growth By Promoting Angiogenesis.Stem Cells 2017 Sep, 35 (9), 2060-2070(IF= 5.2)
9. Yu Liu, Guoyou Yang, Junfeng Zhang, Kaiyan Xing, Lei Dai, Lin Cheng, Junli Liu, Jie Deng, Gang Shi, Chunlei Li, Xiaolan Su, Shuang Zhang, Yang Yang, Jia Li, Dechao Yu, Rong Xiang, Yuquan Wei, Hongxin Deng. Anti-TNF-α Monoclonal Antibody Reverses Psoriasis Through Dual Inhibition of Inflammation and Angiogenesis. Int Immunopharmacol, 2015 Sep 28 (1), 731-43 (IF= 5.6)
10. Junfeng Zhang, Hongwei Tian, Can Li, Lin Cheng, Shuang Zhang, Xiaomei Zhang, Ruibo Wang, Fen Xu, Lei Dai, Gang Shi, Xiaolei Chen, Yiming Li, Tao Du, Jie Deng, Yu Liu, Yang Yang, Yuquan Wei, Hongxin Deng. Antitumor Effects Obtained by Autologous Lewis Lung Cancer Cell Vaccine Engineered to Secrete Mouse Interleukin 27 by Means of Cationic Liposome. Mol Immunol, 2013,Oct, 55 (3-4), 264-74 (IF= 3.6)
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